Over the last decade, partnerships between colleges and universities, government, and businesses have helped foster economic development in the city of Worcester, Massachusetts. In 2006, the Worcester UniverCity Partnership, a coalition of private and public sector organizations working with colleges, in collaboration with the New England Resource Center for Higher Education, organized a speaker series aimed at promoting the depth and impact of university-community partnerships in the city. This report provides highlights from the 2006 Worcester Speaker Series, discusses the history and characteristics of Worcester’s partnerships, and suggests steps toward a workable action agenda for the city. This is a portrait of one city’s approach to strengthening its partnerships, which can also serve as a model for other cities interested in promoting economic development through university-community partnerships.